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Supplementary information Source data Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

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Patients and methods This study was conducted on 19 patients (divided into 2 groups) complaining of melasma selected from dermatology outpatient clinic of Minia University Hospital after approval of the Committee for Postgraduate Studies and Research of Minia University (Approval No.337:11/2019)